There is currently limited understanding of the professional issues associated with practice as a pharmacist in Australia and how this impacts on pharmacists. Anecdotally some pharmacists have indicated that they are required to work in an unsafe, unethical or unprofessional environment which may be detrimental to their well-being. The Pharmacists' Support Service (PSS) is an independent organisation that provides peer support over the telephone to pharmacists with concerns regarding professional practice and their own well-being. This is a pilot study to explore the key reasons pharmacists telephone the PSS. De-identified data from call records between January 2006 and August 2012 were analysed. All callers are encouraged to remain anonymous and data is collected in a manner which excludes information which may identify a caller. Reasons for telephone calls to the PSS were identified. Over this time 276 calls were made to PSS. The majority of callers were female(62%) and the most common age group was below 30 years (24%). The common reasons for calls were stress(23%), workplace/workload issues(12%) and victims of crime(12%). 50% of the “stress” callers indicated that they felt under pressure from their dispensing workload. Personal affairs(4%), substance abuse(4%) and mental health(1%) were other reasons for seeking assistance. The PSS is an invaluable service provided to support and empower pharmacists in Australia. However, lack of infrastructure and inadequate funding limits the ability of the service to reach its full potential. Further funding is required to provide a comprehensive national service.